Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50168673
Substrate
n/a
Meas. Tech.
ChEMBL_303075 (CHEMBL828178)
Ki
260±n/a nM
Citation
Tran, JA; Pontillo, J; Arellano, M; Fleck, BA; Tucci, FC; Marinkovic, D; Chen, CW; Saunders, J; Foster, AC; Chen, C Structure-activity relationship of a series of cyclohexylpiperidines bearing an amide side chain as antagonists of the human melanocortin-4 receptor. Bioorg Med Chem Lett 15:3434-8 (2005) [PubMed] Article
More Info.:
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
Inhibitor
Name:
BDBM50168673
Synonyms:
4-[3-(1-{4-[(R)-2-(3-Amino-propionylamino)-3-(2,4-dichloro-phenyl)-propionyl]-piperazin-1-yl}-cyclohexylmethyl)-ureido]-benzoic acid methyl ester | CHEMBL188980
Type:
Small organic molecule
Emp. Form.:
C32H42Cl2N6O5
Mol. Mass.:
661.619
SMILES:
COC(=O)c1ccc(NC(=O)NCC2(CCCCC2)N2CCN(CC2)C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)CCN)cc1