Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50168676
Substrate
n/a
Meas. Tech.
ChEMBL_303075 (CHEMBL828178)
Ki
220±n/a nM
Citation
 Tran, JA; Pontillo, J; Arellano, M; Fleck, BA; Tucci, FC; Marinkovic, D; Chen, CW; Saunders, J; Foster, AC; Chen, C Structure-activity relationship of a series of cyclohexylpiperidines bearing an amide side chain as antagonists of the human melanocortin-4 receptor. Bioorg Med Chem Lett 15:3434-8 (2005) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50168676
Synonyms:
1,6-Dihydro-pyridine-3-carboxylic acid (1-{4-[2-((R)-3-amino-propionylamino)-3-(2,4-dichloro-phenyl)-propionyl]-piperazin-1-yl}-cyclohexylmethyl)-amide | CHEMBL363239
Type:
Small organic molecule
Emp. Form.:
C29H40Cl2N6O3
Mol. Mass.:
591.572
SMILES:
NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)C1(CNC(=O)C2=CCCN=C2)CCCCC1 |c:35,t:31|
Structure:
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