Reaction Details Report a problem with these data
Target
alpha-1,2-Mannosidase
Ligand
BDBM50168989
Substrate
n/a
Meas. Tech.
ChEMBL_305169 (CHEMBL832759)
IC50
55000±n/a nM
Citation
 Fiaux, H; Popowycz, F; Favre, S; Schütz, C; Vogel, P; Gerber-Lemaire, S; Juillerat-Jeanneret, L Functionalized pyrrolidines inhibit alpha-mannosidase activity and growth of human glioblastoma and melanoma cells. J Med Chem 48:4237-46 (2005) [PubMed]  Article 
Target
Name:
alpha-1,2-Mannosidase
Synonyms:
Alpha-mannosidase
Type:
PROTEIN
Mol. Mass.:
65344.50
Organism:
Glycine max
Description:
ChEMBL_32380
Residue:
578
Sequence:
MARGSRSVGSSSSKWRYCNPSYYLKRPKRLALLFIVFVCVSFVFWDRQTLVREHQVEISELQKEVTDLKNLVDDLNNKQGGTSGKTDLGRKATKSSKDVLDDPIDIERREKVKEAMLHAWGSYEKYAWGQDELQPQSKNGVNSFGGLGATLIDSLDTLYIMGLNEQFQKAREWVANSLDFNKDYEASVFETTIRVVGGLLSAYDLSGDKVFLDKAIEIADRLLPAWNTPTGIPYNIINLSHGRAHNPSWTGGESILADSGTEQLEFIVLSQRTGDLKYQQKVENVIAQLNKTFPDDGLLPIYINPHSGAAGYSPITFGAMGDSFYEYLLKVWIQGNKTSSIKHYRDMWEKSMKGLSSLIRRSTPSSFTYICEKNGGSLTDKMDELACFAPGMIALGSFGYSAADDSQKFLSLAEELAWTCYNFYQSTPTKLAGENYFFHSGQDMSVGTSWNILRPETVESLFYLWRLTGNKTYQEWGWNIFQAFEKNSRIESGYVGLKDVNSGVKDNMMQSFFLAETLKYFYLLFSPSSVISLDEWVFNTEAHPLRIVTRHEEGLVKNLNEKQKPFSRIGGRKEGRSG
  
Inhibitor
Name:
BDBM50168989
Synonyms:
4-Bromo-benzoic acid 2-[((2R,3R,4S)-3,4-dihydroxy-pyrrolidin-2-ylmethyl)-amino]-2-phenyl-ethyl ester | CHEMBL435112
Type:
Small organic molecule
Emp. Form.:
C20H23BrN2O4
Mol. Mass.:
435.312
SMILES:
O[C@H]1CN[C@H](CNC(COC(=O)c2ccc(Br)cc2)c2ccccc2)[C@H]1O
Structure:
Search PDB for entries with ligand similarity: