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Target
D(3) dopamine receptor
Ligand
BDBM50273936
Substrate
n/a
Meas. Tech.
ChEMBL_2215489 (CHEMBL5128621)
EC50
2.9±n/a nM
Citation
 Zhong, Z; He, X; Ge, J; Zhu, J; Yao, C; Cai, H; Ye, XY; Xie, T; Bai, R Discovery of small-molecule compounds and natural products against Parkinson's disease: Pathological mechanism and structural modification. Eur J Med Chem 237:0 (2022) [PubMed] 
Target
Name:
D(3) dopamine receptor
Synonyms:
DRD3 | DRD3_HUMAN | Dopamine D3 receptor
Type:
PROTEIN
Mol. Mass.:
44213.40
Organism:
Homo sapiens
Description:
ChEMBL_105671
Residue:
400
Sequence:
MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50273936
Synonyms:
(S)-7-((2-(4-phenylpiperazin-1-yl)ethyl)(propyl)amino)-5,6,7,8-tetrahydronaphthalen-2-ol | CHEMBL458088
Type:
Small organic molecule
Emp. Form.:
C25H35N3O
Mol. Mass.:
393.5649
SMILES:
CCCN(CCN1CCN(CC1)c1ccccc1)[C@H]1CCc2ccc(O)cc2C1 |r|
Structure:
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