Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50169528
Substrate
n/a
Meas. Tech.
ChEMBL_303113 (CHEMBL829622)
Ki
1600±n/a nM
Citation
 Han, X; Pin, SS; Burris, K; Fung, LK; Huang, S; Taber, MT; Zhang, J; Dubowchik, GM Synthesis and structure-activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists. Bioorg Med Chem Lett 15:4029-32 (2005) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Human
Description:
P34998
Residue:
415
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50169528
Synonyms:
CHEMBL362124 | [9-(2,4-Dichloro-phenyl)-2-trifluoromethyl-9H-benzo[d]imidazo[1,2-a]imidazol-3-ylmethyl]-phenethyl-propyl-amine
Type:
Small organic molecule
Emp. Form.:
C28H25Cl2F3N4
Mol. Mass.:
545.426
SMILES:
CCCN(CCc1ccccc1)Cc1c(nc2n(-c3ccc(Cl)cc3Cl)c3ccccc3n12)C(F)(F)F |(7.76,.46,;6.27,.06,;5.86,-1.42,;4.38,-1.8,;3.29,-.71,;3.71,.78,;2.63,1.88,;1.15,1.48,;.07,2.58,;.47,4.07,;1.97,4.47,;3.04,3.36,;3.97,-3.29,;5.04,-4.39,;4.79,-5.92,;6.16,-6.63,;7.27,-5.55,;8.8,-5.32,;9.87,-6.41,;9.46,-7.89,;10.54,-8.98,;12.03,-8.6,;13.11,-9.7,;12.43,-7.11,;11.36,-6.02,;11.76,-4.53,;9.05,-3.8,;10.35,-2.97,;10.28,-1.43,;8.9,-.72,;7.61,-1.55,;7.68,-3.08,;6.58,-4.16,;3.41,-6.6,;2.15,-7.23,;1.94,-5.94,;3.05,-8.17,)|
Structure:
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