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Target
Short transient receptor potential channel 4
Ligand
BDBM49021
Substrate
n/a
Meas. Tech.
ChEMBL_2216155 (CHEMBL5129287)
IC50
77200±n/a nM
Citation
 Chen, L; Zhang, Z; Tian, H; Jiang, S; Ji, Y; Liu, M; Shen, J; Cao, Z; Wang, K Synthesis of AC1903 analogs as potent transient receptor potential canonical channel 4/5 inhibitors and biological evaluation. Bioorg Med Chem 68:0 (2022) [PubMed] 
Target
Name:
Short transient receptor potential channel 4
Synonyms:
Short transient receptor potential channel 4 | TRPC4 | TRPC4_HUMAN | Trp-related protein 4 | hTrp-4 | hTrp4
Type:
PROTEIN
Mol. Mass.:
112112.80
Organism:
Homo sapiens
Description:
ChEMBL_118216
Residue:
977
Sequence:
MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGRRAADNLRRHHQYQEVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESSNSADSDEKSDSEGNSKDKKKNFSLFDLTTLIHPRSAAIASERHNISNGSALVVQEPPREKQRKVNFVTDIKNFGLFHRRSKQNAAEQNANQIFSVSEEVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDHRERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHEDYVTTRL
  
Inhibitor
Name:
BDBM49021
Synonyms:
(1-benzylbenzimidazol-2-yl)-(2-furfuryl)amine | 1-benzyl-N-(furan-2-ylmethyl)benzimidazol-2-amine | MLS000084083 | N-(2-furanylmethyl)-1-(phenylmethyl)-2-benzimidazolamine | N-(furan-2-ylmethyl)-1-(phenylmethyl)benzimidazol-2-amine | SMR000048469 | cid_667146
Type:
Small organic molecule
Emp. Form.:
C19H17N3O
Mol. Mass.:
303.3578
SMILES:
C(Nc1nc2ccccc2n1Cc1ccccc1)c1ccco1
Structure:
Search PDB for entries with ligand similarity: