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Target
Histone deacetylase 8
Ligand
BDBM50595333
Substrate
n/a
Meas. Tech.
ChEMBL_2216192 (CHEMBL5129324)
Kd
5.4±n/a nM
Citation
 Huang, C; Shu, Y; Zhu, Y; Liu, H; Wang, X; Wen, H; Liu, J; Li, W Discovery of non-substrate, environmentally sensitive turn-on fluorescent probes for imaging HDAC8 in tumor cells and tissue slices. Bioorg Med Chem 68:0 (2022) [PubMed] 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50595333
Synonyms:
CHEMBL5197578
Type:
Small organic molecule
Emp. Form.:
C28H29N7O7S
Mol. Mass.:
607.638
SMILES:
COc1ccc(Cn2ccc3ccc(cc23)C(=O)NO)cc1C(=O)NCCNc1ccc(c2nonc12)S(=O)(=O)N(C)C
Structure:
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