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Target
Cathepsin K
Ligand
BDBM50148291
Substrate
n/a
Meas. Tech.
ChEMBL_306541 (CHEMBL827830)
IC50
2.7±n/a nM
Citation
 Tavares, FX; Deaton, DN; Miller, AB; Miller, LR; Wright, LL Ketoheterocycle-based inhibitors of cathepsin K: a novel entry into the synthesis of peptidic ketoheterocycles. Bioorg Med Chem Lett 15:3891-5 (2005) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50148291
Synonyms:
((S)-1-Formyl-pentyl)-carbamic acid (S)-2-cyclohexyl-1-methyl-ethyl ester | (S)-1-cyclohexylpropan-2-yl (S)-1-oxohexan-2-ylcarbamate | CHEMBL116402
Type:
Small organic molecule
Emp. Form.:
C16H29NO3
Mol. Mass.:
283.4064
SMILES:
CCCC[C@H](NC(=O)O[C@@H](C)CC1CCCCC1)C=O
Structure:
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