Reaction Details Report a problem with these data
Target
Cathepsin K
Ligand
BDBM50169763
Substrate
n/a
Meas. Tech.
ChEMBL_306541 (CHEMBL827830)
IC50
>13000±n/a nM
Citation
 Tavares, FX; Deaton, DN; Miller, AB; Miller, LR; Wright, LL Ketoheterocycle-based inhibitors of cathepsin K: a novel entry into the synthesis of peptidic ketoheterocycles. Bioorg Med Chem Lett 15:3891-5 (2005) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50169763
Synonyms:
2-[2-(2-Propoxy-benzoylamino)-acetyl]-thiazole-4-carboxylic acid ethyl ester | CHEMBL183647
Type:
Small organic molecule
Emp. Form.:
C18H20N2O5S
Mol. Mass.:
376.427
SMILES:
CCCOc1ccccc1C(=O)NCC(=O)c1nc(cs1)C(=O)OCC
Structure:
Search PDB for entries with ligand similarity: