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Target
Cathepsin K
Ligand
BDBM50169765
Substrate
n/a
Meas. Tech.
ChEMBL_306541 (CHEMBL827830)
IC50
8100±n/a nM
Citation
 Tavares, FX; Deaton, DN; Miller, AB; Miller, LR; Wright, LL Ketoheterocycle-based inhibitors of cathepsin K: a novel entry into the synthesis of peptidic ketoheterocycles. Bioorg Med Chem Lett 15:3891-5 (2005) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50169765
Synonyms:
(S)-1-cyclohexylpropan-2-yl (S)-1-(5-methyl-1,2,4-oxadiazol-3-yl)-1-oxohexan-2-ylcarbamate | CHEMBL360237 | [(S)-1-(5-Methyl-[1,2,4]oxadiazole-3-carbonyl)-pentyl]-carbamic acid (S)-2-cyclohexyl-1-methyl-ethyl ester
Type:
Small organic molecule
Emp. Form.:
C19H31N3O4
Mol. Mass.:
365.4671
SMILES:
CCCC[C@H](NC(=O)O[C@@H](C)CC1CCCCC1)C(=O)c1noc(C)n1
Structure:
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