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Target
Cathepsin K
Ligand
BDBM50169767
Substrate
n/a
Meas. Tech.
ChEMBL_306541 (CHEMBL827830)
IC50
230±n/a nM
Citation
 Tavares, FX; Deaton, DN; Miller, AB; Miller, LR; Wright, LL Ketoheterocycle-based inhibitors of cathepsin K: a novel entry into the synthesis of peptidic ketoheterocycles. Bioorg Med Chem Lett 15:3891-5 (2005) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50169767
Synonyms:
2-[(S)-2-((S)-2-Cyclohexyl-1-methyl-ethoxycarbonylamino)-hexanoyl]-thiazole-4-carboxylic acid ethyl ester | CHEMBL361816 | ethyl 2-((S)-2-(((S)-1-cyclohexylpropan-2-yloxy)carbonyl)hexanoyl)thiazole-4-carboxylate
Type:
Small organic molecule
Emp. Form.:
C22H34N2O5S
Mol. Mass.:
438.581
SMILES:
CCCC[C@H](NC(=O)O[C@@H](C)CC1CCCCC1)C(=O)c1nc(cs1)C(=O)OCC
Structure:
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