Reaction Details
Report a problem with these data
Report a problem with these dataTarget
17-beta-hydroxysteroid dehydrogenase type 1
Ligand
BDBM50587607
Substrate
n/a
Meas. Tech.
ChEMBL_2217338 (CHEMBL5130470)
IC50
2.7±n/a nM
Citation
Mohamed, A; Salah, M; Tahoun, M; Hawner, M; Abdelsamie, AS; Frotscher, M Dual Targeting of Steroid Sulfatase and 17?-Hydroxysteroid Dehydrogenase Type 1 by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of Endometriosis. J Med Chem 65:11726-11744 (2022) [PubMed] More Info.:
Target
Name:
17-beta-hydroxysteroid dehydrogenase type 1
Synonyms:
17-beta-HSD 1 | 17-beta-Hydroxysteroid Dehydrogenase 1 (17-beta-HSD1) | 17-beta-hydroxysteroid dehydrogenase type 1 | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | DHB1_HUMAN | E17KSR | E2DH | EDH17B1 | EDH17B2 | EDHB17 | Estradiol 17-beta-dehydrogenase 1 | Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1) | HSD17B1 | Placental 17-beta-hydroxysteroid dehydrogenase | SDR28C1
Type:
Enzyme
Mol. Mass.:
34945.13
Organism:
Homo sapiens (Human)
Description:
P14061
Residue:
328
Sequence:
MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGGGAGPGAEDEAGRGAVGDPELGDPPAAPQ
Inhibitor
Name:
BDBM50587607
Synonyms:
CHEMBL5089787
Type:
Small organic molecule
Emp. Form.:
C19H16ClNO3
Mol. Mass.:
341.788
SMILES:
CN(C(=O)c1ccc(o1)-c1ccc(O)c(Cl)c1)c1ccccc1C
Structure:
