Reaction Details Report a problem with these data
Target
Tubulin beta chain [1-43]
Ligand
BDBM50170572
Substrate
n/a
Meas. Tech.
ChEMBL_311661 (CHEMBL840833)
IC50
3100±n/a nM
Citation
Romagnoli, R; Baraldi, PG; Jung, MK; Iaconinoto, MA; Carrion, MD; Remusat, V; Preti, D; Tabrizi, MA; Francesca, F; De Clercq, E; Balzarini, J; Hamel, E Synthesis and preliminary biological evaluation of new anti-tubulin agents containing different benzoheterocycles. Bioorg Med Chem Lett 15:4048-52 (2005) [PubMed] Article
More Info.:
Target
Name:
Tubulin beta chain [1-43]
Synonyms:
Beta tubulin | TBB_LEIME
Type:
PROTEIN
Mol. Mass.:
4652.47
Organism:
Leishmania donovani
Description:
ChEMBL_311916
Residue:
43
Sequence:
MREIVSCQAGQCGNQIGSKFWEVIADEHGVDPTGSYQGDSDLQ
Inhibitor
Name:
BDBM50170572
Synonyms:
(2-Amino-benzo[b]thiophen-3-yl)-(3,4,5-trimethoxy-phenyl)-methanone | (2-amino-benzo[b]thiophen-3-yl)-(3,4,5-trimethoxyphenyl)-methanone | (2-aminobenzo[b]thiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone | CHEMBL189355
Type:
Small organic molecule
Emp. Form.:
C18H17NO4S
Mol. Mass.:
343.397
SMILES:
COc1cc(cc(OC)c1OC)C(=O)c1c(N)sc2ccccc12