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Target
Kappa-type opioid receptor
Ligand
BDBM50170676
Substrate
n/a
Meas. Tech.
ChEMBL_302816 (CHEMBL839506)
Ki
2.3±n/a nM
Citation
 Harding, WW; Tidgewell, K; Byrd, N; Cobb, H; Dersch, CM; Butelman, ER; Rothman, RB; Prisinzano, TE Neoclerodane diterpenes as a novel scaffold for mu opioid receptor ligands. J Med Chem 48:4765-71 (2005) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM50170676
Synonyms:
(2S,4aR,6aR,7R,9S,10aS,10bR)-methyl 2-(furan-3-yl)-6a,10b-dimethyl-9-(methylsulfonyloxy)-4,10-dioxo-dodecahydro-1H-benzo[f]isochromene-7-carboxylate | (3S,4aR,4bS,6S,8R,8aR,10aR)-3-Furan-3-yl-6-methanesulfonyloxy-4a,8a-dimethyl-1,5-dioxo-dodecahydro-2-oxa-phenanthrene-8-carboxylic acid methyl ester | CHEMBL365216
Type:
Small organic molecule
Emp. Form.:
C22H28O9S
Mol. Mass.:
468.517
SMILES:
COC(=O)[C@@H]1C[C@H](OS(C)(=O)=O)C(=O)[C@H]2[C@@]1(C)CC[C@H]1C(=O)O[C@@H](C[C@]21C)c1ccoc1 |r|
Structure:
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