Reaction Details
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Elongation of very long chain fatty acids protein 1
Ligand
BDBM50596133
Substrate
n/a
Meas. Tech.
ChEMBL_2219492 (CHEMBL5132826)
IC50
13±n/a nM
Citation
Come, JH; Senter, TJ; Clark, MP; Court, JJ; Gale-Day, Z; Gu, W; Krueger, E; Liang, J; Morris, M; Nanthakumar, S; O'Dowd, H; Maltais, F; Iyer, G; Andreassi, J; Boucher, C; Considine, T; Moody, CS; Taylor, W; Mohanty, AK; Huang, Y; Zuccola, H; Coll, J; Bonanno, KC; Gagnon, KJ; Gan, L; Lu, F; Gao, H; Chakilam, A; Engtrakul, J; Song, B; Crawford, D; Doyle, E; Kramer, T; Vought, B; Phillips, J; Kemper, R; Sanders, M; Swett, R; Furey, B; Winquist, R; Bunnage, ME; Jackson, KL; Charifson, PS; Magavi, SS Discovery and Optimization of Pyrazole Amides as Inhibitors of ELOVL1. J Med Chem 64:17753-17776 (2021) [PubMed] More Info.:
Target
Name:
Elongation of very long chain fatty acids protein 1
Synonyms:
ELOV1_HUMAN | ELOVL1 | SSC1
Type:
PROTEIN
Mol. Mass.:
32679.45
Organism:
Homo sapiens (Human)
Description:
ChEMBL_572241
Residue:
279
Sequence:
MEAVVNLYQEVMKHADPRIQGYPLMGSPLLMTSILLTYVYFVLSLGPRIMANRKPFQLRGFMIVYNFSLVALSLYIVYEFLMSGWLSTYTWRCDPVDYSNSPEALRMVRVAWLFLFSKFIELMDTVIFILRKKDGQVTFLHVFHHSVLPWSWWWGVKIAPGGMGSFHAMINSSVHVIMYLYYGLSAFGPVAQPYLWWKKHMTAIQLIQFVLVSLHISQYYFMSSCNYQYPVIIHLIWMYGTIFFMLFSNFWYHSYTKGKRLPRALQQNGAPGIAKVKAN
Inhibitor
Name:
BDBM50596133
Synonyms:
CHEMBL5081193
Type:
Small organic molecule
Emp. Form.:
C18H14F2N4O
Mol. Mass.:
340.3268
SMILES:
Fc1cc(ccn1)-n1ccc(NC(=O)C2(CC2)c2ccccc2F)n1
Structure:
