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Target
Serine/threonine-protein kinase receptor R3
Ligand
BDBM102619
Substrate
n/a
Meas. Tech.
ChEMBL_2219784 (CHEMBL5133118)
IC50
1.8±n/a nM
Citation
 Witten, MR; Wu, L; Lai, CT; Kapilashrami, K; Pusey, M; Gallagher, K; Chen, Y; Yao, W Inhibition of ALK2 with bicyclic pyridyllactams. Bioorg Med Chem Lett 55:0 (2022) [PubMed] 
Target
Name:
Serine/threonine-protein kinase receptor R3
Synonyms:
ACVL1_HUMAN | ACVRL1 | ACVRLK1 | ALK1 | Activin receptor-like kinase 1 (ALK-1) | Serine/threonine-protein kinase receptor R3 (ALK1)
Type:
Enzyme
Mol. Mass.:
56134.46
Organism:
Homo sapiens (Human)
Description:
P37023
Residue:
503
Sequence:
MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLALILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISNSPEKPKVIQ
  
Inhibitor
Name:
BDBM102619
Synonyms:
K02288a | US10688093, Compound 382_0087_0284 | US11701353, Compound 382_0087_0284
Type:
Small organic molecule
Emp. Form.:
C20H20N2O4
Mol. Mass.:
352.3838
SMILES:
COc1cc(cc(OC)c1OC)-c1cc(cnc1N)-c1cccc(O)c1
Structure:
Search PDB for entries with ligand similarity: