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Target
Cathepsin E
Ligand
BDBM50596254
Substrate
n/a
Meas. Tech.
ChEMBL_2219940 (CHEMBL5133274)
Ki
>30550±n/a nM
Citation
 Taoka, BM; Wu, WL; Hao, J; Dolmaski, M; Wang, H; Levorse, D; Orth, P; Hyde, LA; Smith, B; Michener, MS; Kennedy, ME; Parker, EM; Cumming, JN Design and discovery of C2-fluoroalkyl iminothiazine dioxides as BACE inhibitors. Bioorg Med Chem Lett 56:0 (2022) [PubMed] 
Target
Name:
Cathepsin E
Synonyms:
3.4.23.34 | CATE_HUMAN | CTSE | Cathepsin E form I | Cathepsin E form II
Type:
Enzyme
Mol. Mass.:
43298.99
Organism:
Homo sapiens (Human)
Description:
P14091
Residue:
396
Sequence:
MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGAAPVDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDIHPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAPAVP
  
Inhibitor
Name:
BDBM50596254
Synonyms:
CHEMBL5198665
Type:
Small organic molecule
Emp. Form.:
C20H19F3N6O3S
Mol. Mass.:
480.463
SMILES:
Cc1cc(cnc1C(=O)Nc1ccc(F)c(n1)[C@]1(C)CS(=O)(=O)[C@@](C)(C(F)F)C(=N)N1)C#N |r|
Structure:
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