Reaction Details Report a problem with these data
Target
P2X purinoceptor 5
Ligand
BDBM50596631
Substrate
n/a
Meas. Tech.
ChEMBL_2221596 (CHEMBL5134930)
IC50
7010±n/a nM
Citation
 Mahmood, A; Ali Shah, SJ; Iqbal, J Design and synthesis of adamantane-1-carbonyl thiourea derivatives as potent and selective inhibitors of h-P2X4 and h-P2X7 receptors: An Emerging therapeutic tool for treatment of inflammation and neurological disorders. Eur J Med Chem 231:0 (2022) [PubMed] 
Target
Name:
P2X purinoceptor 5
Synonyms:
ATP receptor | P2RX5 | P2RX5_HUMAN | P2X5 | Purinergic receptor
Type:
PROTEIN
Mol. Mass.:
47208.74
Organism:
Homo sapiens (Human)
Description:
ChEMBL_612725
Residue:
422
Sequence:
MGQAGCKGLCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDTSLQSAVITKVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTPNQRQNVCAENEGIPDGACSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLETSSRPEEPFLKEAEDFTIFIKNHIRFPKFNFSKSNVMDVKDRSFLKSCHFGPKNHYCPIFRLGSVIRWAGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNKLSKSVSSGYNFRFARYYRDAAGVEFRTLMKAYGIRFDVMVNGKGAFFCDLVLIYLIKKREFYRDKKYEEVRGLEDSSQEAEDEASGLGLSEQLTSGPGLLGMPEQQELQEPPEAKRGSSSQKGNGSVCPQLLEPHRST
  
Inhibitor
Name:
BDBM50596631
Synonyms:
CHEMBL1615626
Type:
Small organic molecule
Emp. Form.:
C15H15N2O12PS2
Mol. Mass.:
510.39
SMILES:
Cc1cc(\N=N\c2ccc(cc2S(O)(=O)=O)S(O)(=O)=O)c(COP(O)(O)=O)c(C=O)c1O
Structure:
Search PDB for entries with ligand similarity: