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Target
Melanin-concentrating hormone receptor 2
Ligand
BDBM50172438
Substrate
n/a
Meas. Tech.
ChEMBL_321623 (CHEMBL871632)
IC50
>10±n/a nM
Citation
 Ulven, T; Frimurer, TM; Receveur, JM; Little, PB; Rist, O; Nørregaard, PK; Högberg, T 6-Acylamino-2-aminoquinolines as potent melanin-concentrating hormone 1 receptor antagonists. Identification, structure-activity relationship, and investigation of binding mode. J Med Chem 48:5684-97 (2005) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 2
Synonyms:
GPR145 | MCHR2 | MCHR2_HUMAN | Melanin Concentrating Hormone 2 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 2 | SLT
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38862.16
Organism:
Homo sapiens (Human)
Description:
Melanin Concentrating Hormone 2 GPR145 HUMAN::Q969V1
Residue:
340
Sequence:
MNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
  
Inhibitor
Name:
BDBM50172438
Synonyms:
CHEMBL194691 | N-{2-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-4-methyl-quinolin-6-yl}-2-(4-trifluoromethoxy-phenoxy)-acetamide
Type:
Small organic molecule
Emp. Form.:
C26H29F3N4O3
Mol. Mass.:
502.5287
SMILES:
CCN1CCCC1CNc1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Structure:
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