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Target
Melanin-concentrating hormone receptor 2
Ligand
BDBM50172432
Substrate
n/a
Meas. Tech.
ChEMBL_321623 (CHEMBL871632)
IC50
4.5±n/a nM
Citation
 Ulven, T; Frimurer, TM; Receveur, JM; Little, PB; Rist, O; Nørregaard, PK; Högberg, T 6-Acylamino-2-aminoquinolines as potent melanin-concentrating hormone 1 receptor antagonists. Identification, structure-activity relationship, and investigation of binding mode. J Med Chem 48:5684-97 (2005) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 2
Synonyms:
GPR145 | MCHR2 | MCHR2_HUMAN | Melanin Concentrating Hormone 2 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 2 | SLT
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38862.16
Organism:
Homo sapiens (Human)
Description:
Melanin Concentrating Hormone 2 GPR145 HUMAN::Q969V1
Residue:
340
Sequence:
MNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
  
Inhibitor
Name:
BDBM50172432
Synonyms:
2-(2,4-Dichloro-phenoxy)-N-{2-[(2-dimethylamino-ethyl)-methyl-amino]-4-methyl-quinolin-6-yl}-acetamide | CHEMBL194408
Type:
Small organic molecule
Emp. Form.:
C23H26Cl2N4O2
Mol. Mass.:
461.384
SMILES:
CN(C)CCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Structure:
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