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Target
Pyruvate kinase PKLR
Ligand
BDBM50596775
Substrate
n/a
Meas. Tech.
ChEMBL_2222229 (CHEMBL5135563)
IC50
3800±n/a nM
Citation
 Nain-Perez, A; Foller Füchtbauer, A; Hĺversen, L; Lulla, A; Gao, C; Matic, J; Monjas, L; Rodríguez, A; Brear, P; Kim, W; Hyvönen, M; Borén, J; Mardinoglu, A; Uhlen, M; Grřtli, M Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase. Eur J Med Chem 234:0 (2022) [PubMed] 
Target
Name:
Pyruvate kinase PKLR
Synonyms:
KPYR_HUMAN | PK1 | PK1 | PKL | PKLR | Pyruvate kinase 1 | Pyruvate kinase PKLR | Pyruvate kinase isozymes L/R | R-type/L-type pyruvate kinase | Red cell/liver pyruvate kinase
Type:
PROTEIN
Mol. Mass.:
61835.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_103054
Residue:
574
Sequence:
MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS
  
Inhibitor
Name:
BDBM50596775
Synonyms:
CHEMBL5169856
Type:
Small organic molecule
Emp. Form.:
C23H17NO6
Mol. Mass.:
403.3842
SMILES:
OC(=O)Cc1ccc(CNc2cc3C(=O)c4ccccc4C(=O)c3c(O)c2O)cc1
Structure:
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