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Target
B-cell lymphoma 6 protein
Ligand
BDBM50597108
Substrate
n/a
Meas. Tech.
ChEMBL_2222868 (CHEMBL5136202)
IC50
3.9±n/a nM
Citation
 Davis, OA; Cheung, KJ; Brennan, A; Lloyd, MG; Rodrigues, MJ; Pierrat, OA; Collie, GW; Le Bihan, YV; Huckvale, R; Harnden, AC; Varela, A; Bright, MD; Eve, P; Hayes, A; Henley, AT; Carter, MD; McAndrew, PC; Talbot, R; Burke, R; van Montfort, RLM; Raynaud, FI; Rossanese, OW; Meniconi, M; Bellenie, BR; Hoelder, S Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors. J Med Chem 65:8169-8190 (2022) [PubMed] 
Target
Name:
B-cell lymphoma 6 protein
Synonyms:
B-cell lymphoma 5 protein | B-cell lymphoma 6 protein | BCL-5 | BCL-6 | BCL5 | BCL6 | BCL6_HUMAN | BCoR-BCL6 | LAZ3 | Protein LAZ-3 | ZBTB27 | ZNF51 | Zinc finger and BTB domain-containing protein 27 | Zinc finger protein 51
Type:
PROTEIN
Mol. Mass.:
78866.89
Organism:
Homo sapiens
Description:
ChEMBL_117695
Residue:
706
Sequence:
MASPADSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFCILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFIKASEAEMVSAIKPPREEFLNSRMLMPQDIMAYRGREVVENNLPLRSAPGCESRAFAPSLYSGLSTPPASYSMYSHLPVSSLLFSDEEFRDVRMPVANPFPKERALPCDSARPVPGEYSRPTLEVSPNVCHSNIYSPKETIPEEARSDMHYSVAEGLKPAAPSARNAPYFPCDKASKEEERPSSEDEIALHFEPPNAPLNRKGLVSPQSPQKSDCQPNSPTESCSSKNACILQASGSPPAKSPTDPKACNWKKYKFIVLNSLNQNAKPEGPEQAELGRLSPRAYTAPPACQPPMEPENLDLQSPTKLSASGEDSTIPQASRLNNIVNRSMTGSPRSSSESHSPLYMHPPKCTSCGSQSPQHAEMCLHTAGPTFPEEMGETQSEYSDSSCENGAFFCNECDCRFSEEASLKRHTLQTHSDKPYKCDRCQASFRYKGNLASHKTVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEKPYKCETCGARFVQVAHLRAHVLIHTGEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYHCEKCNLHFRHKSQLRLHLRQKHGAITNTKVQYRVSATDLPPELPKAC
  
Inhibitor
Name:
BDBM50597108
Synonyms:
CHEMBL5184251 | US20230287003, Example 1v
Type:
Small organic molecule
Emp. Form.:
C22H18ClF2N5O2
Mol. Mass.:
457.86
SMILES:
Cn1c2ccc(Nc3ccnc(Cl)c3C#N)cc2c2N[C@@H](C3CC3)C(F)(F)COc2c1=O |r|
Structure:
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