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Target
tRNA (cytosine(38)-C(5))-methyltransferase
Ligand
BDBM50009672
Substrate
n/a
Meas. Tech.
ChEMBL_2223595 (CHEMBL5136929)
Kd
13600±n/a nM
Citation
 Schwickert, M; Fischer, TR; Zimmermann, RA; Hoba, SN; Meidner, JL; Weber, M; Weber, M; Stark, MM; Koch, J; Jung, N; Kersten, C; Windbergs, M; Lyko, F; Helm, M; Schirmeister, T Discovery of Inhibitors of DNA Methyltransferase 2, an Epitranscriptomic Modulator and Potential Target for Cancer Treatment. J Med Chem 65:9750-9788 (2022) [PubMed] 
Target
Name:
tRNA (cytosine(38)-C(5))-methyltransferase
Synonyms:
2.1.1.204 | DNA (cytosine-5)-methyltransferase-like protein 2 | DNA MTase homolog HsaIIP | DNA methyltransferase homolog HsaIIP | DNMT2 | M.HsaIIP | PuMet | TRDMT1 | TRDMT_HUMAN
Type:
PROTEIN
Mol. Mass.:
44593.53
Organism:
Homo sapiens
Description:
ChEMBL_118874
Residue:
391
Sequence:
MEPLRVLELYSGVGGMHHALRESCIPAQVVAAIDVNTVANEVYKYNFPHTQLLAKTIEGITLEEFDRLSFDMILMSPPCQPFTRIGRQGDMTDSRTNSFLHILDILPRLQKLPKYILLENVKGFEVSSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQSEPLPFQAPGQVLMEFPKIESVHPQKYAMDVENKIQEKNVEPNISFDGSIQCSGKDAILFKLETAEEIHRKNQQDSDLSVKMLKDFLEDDTDVNQYLLPPKSLLRYALLLDIVQPTCRRSVCFTKGYGSYIEGTGSVLQTAEDVQVENIYKSLTNLSQEEQITKLLILKLRYFTPKEIANLLGFPPEFGFPEKITVKQRYRLLGNSLNVHVVAKLIKILYE
  
Inhibitor
Name:
BDBM50009672
Synonyms:
AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocysteine | S-(5'-deoxyadenosin-5'-yl)-L-homocysteine | S-[1-(adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl]-L-homocysteine | S-adenosyl-L-homocysteine | SAH | US8895245, S-Adenosyl-L-homocysteine (SAH) | US9175331, 1 | US9333217, S-Adenosyl-L-homocysteine (SAH)
Type:
Small organic molecule
Emp. Form.:
C14H20N6O5S
Mol. Mass.:
384.411
SMILES:
N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Structure:
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