Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4E
Ligand
BDBM297345
Substrate
n/a
Meas. Tech.
ChEMBL_2224138 (CHEMBL5137651)
IC50
430±n/a nM
Citation
 Xu, W; Kannan, S; Verma, CS; Nacro, K Update on the Development of MNK Inhibitors as Therapeutic Agents. J Med Chem 65:983-1007 (2022) [PubMed] 
Target
Name:
Eukaryotic translation initiation factor 4E
Synonyms:
EIF4E | EIF4EL1 | EIF4F | Eukaryotic translation initation factor | Eukaryotic translation initiation factor 4E (eIF4E) | Eukaryotic translation initiation factor 4E/Eukaryotic translation initiation factor 4E-binding protein 1 | IF4E_HUMAN
Type:
Protein
Mol. Mass.:
25095.44
Organism:
Homo sapiens (Human)
Description:
P06730
Residue:
217
Sequence:
MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
  
Inhibitor
Name:
BDBM297345
Synonyms:
N-(6-((1-oxoisoindolin-5-yl)amino)pyrimidin-4-yl)cyclopropanecarboxamide (Cpd. No. 12) | US10112955, Example 12
Type:
Small organic molecule
Emp. Form.:
C16H15N5O2
Mol. Mass.:
309.3226
SMILES:
O=C(Nc1cc(Nc2ccc3C(=O)NCc3c2)ncn1)C1CC1
Structure:
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