Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50175049
Substrate
n/a
Meas. Tech.
ChEMBL_326924 (CHEMBL854316)
Ki
8.6±n/a nM
Citation
 Poulsen, SA; Bornaghi, LF; Healy, PC Synthesis and structure-activity relationships of novel benzene sulfonamides with potent binding affinity for bovine carbonic anhydrase II. Bioorg Med Chem Lett 15:5429-33 (2005) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA2 | CAH2_BOVIN | Carbonic anhydrase | Carbonic anhydrase 2 | Carbonic anhydrase II | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
29115.93
Organism:
Bos taurus
Description:
n/a
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIANGERQSPVDIDTKAVVQDPALKPLALVYGEATSRRMVNNGHSFNVEYDDSQDKAVLKDGPLTGTYRLVQFHFHWGSSDDQGSEHTVDRKKYAAELHLVHWNTKYGDFGTAAQQPDGLAVVGVFLKVGDANPALQKVLDALDSIKTKGKSTDFPNFDPGSLLPNVLDYWTYPGSLTTPPLLESVTWIVLKEPISVSSQQMLKFRTLNFNAEGEPELLMLANWRPAQPLKNRQVRGFPK
  
Inhibitor
Name:
BDBM50175049
Synonyms:
CHEMBL381455 | allyl 4-(aminosulfonyl)benzoate
Type:
Small organic molecule
Emp. Form.:
C10H11NO4S
Mol. Mass.:
241.264
SMILES:
NS(=O)(=O)c1ccc(cc1)C(=O)OCC=C
Structure:
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