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Target
Methionine aminopeptidase
Ligand
BDBM50175458
Substrate
n/a
Meas. Tech.
ChEMBL_326945 (CHEMBL853286)
IC50
170000±n/a nM
Citation
 Huang, QQ; Huang, M; Nan, FJ; Ye, QZ Metalloform-selective inhibition: synthesis and structure-activity analysis of Mn(II)-form-selective inhibitors of Escherichia coli methionine aminopeptidase. Bioorg Med Chem Lett 15:5386-91 (2005) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase
Synonyms:
EcMetAP | MAP1_ECOLI | Methionine Aminopeptidase (MAP) | Methionine aminopeptidase | Peptidase M | map
Type:
Enzyme
Mol. Mass.:
29326.96
Organism:
Escherichia coli (strain K12)
Description:
Full-length untagged EcMAP was expressed in E. coli.
Residue:
264
Sequence:
MAISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
  
Inhibitor
Name:
BDBM50175458
Synonyms:
5-(2-(trifluoromethoxy)phenyl)furan-2-carboxylic acid | 5-[2-(TRIFLUOROMETHOXY)PHENYL]-2-FUROIC ACID | CHEMBL199441
Type:
Small organic molecule
Emp. Form.:
C12H7F3O4
Mol. Mass.:
272.1768
SMILES:
OC(=O)c1ccc(o1)-c1ccccc1OC(F)(F)F
Structure:
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