Reaction Details Report a problem with these data
Target
RISC-loading complex subunit TARBP2
Ligand
BDBM50598488
Substrate
n/a
Meas. Tech.
ChEMBL_2227085 (CHEMBL5140598)
Kd
680±n/a nM
Citation
 Peng, T; He, Y; Wang, T; Yu, J; Ma, X; Zhou, Z; Sheng, Y; Li, L; Peng, H; Li, S; Zou, J; Yuan, Y; Zhao, Y; Shi, H; Li, F; Liu, W; Hu, K; Lu, X; Zhang, G; Wang, F Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP-Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis. J Med Chem 65:11010-11033 (2022) [PubMed] 
Target
Name:
RISC-loading complex subunit TARBP2
Synonyms:
RISC-loading complex subunit TARBP2 | TAR RNA-binding protein 2 | TARBP2 | TRBP | TRBP2_HUMAN | Trans-activation-responsive RNA-binding protein
Type:
PROTEIN
Mol. Mass.:
39038.90
Organism:
Homo sapiens
Description:
ChEMBL_10363
Residue:
366
Sequence:
MSEEEQGSGTTTGCGLPSIEQMLAANPGKTPISLLQEYGTRIGKTPVYDLLKAEGQAHQPNFTFRVTVGDTSCTGQGPSKKAAKHKAAEVALKHLKGGSMLEPALEDSSSFSPLDSSLPEDIPVFTAAAAATPVPSVVLTRSPPMELQPPVSPQQSECNPVGALQELVVQKGWRLPEYTVTQESGPAHRKEFTMTCRVERFIEIGSGTSKKLAKRNAAAKMLLRVHTVPLDARDGNEVEPDDDHFSIGVGSRLDGLRNRGPGCTWDSLRNSVGEKILSLRSCSLGSLGALGPACCRVLSELSEEQAFHVSYLDIEELSLSGLCQCLVELSTQPATVCHGSATTREAARGEAARRALQYLKIMAGSK
  
Inhibitor
Name:
BDBM50598488
Synonyms:
CHEMBL5201452
Type:
Small organic molecule
Emp. Form.:
C15H17NO4
Mol. Mass.:
275.2998
SMILES:
CCOC(=O)c1nc(oc1CC)-c1ccc(OC)cc1
Structure:
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