Reaction Details Report a problem with these data
Target
Nuclear receptor subfamily 4 group A member 2
Ligand
BDBM50318491
Substrate
n/a
Meas. Tech.
ChEMBL_2227565 (CHEMBL5141078)
EC50
5000±n/a nM
Citation
 Willems, S; Merk, D Medicinal Chemistry and Chemical Biology of Nurr1 Modulators: An Emerging Strategy in Neurodegeneration. J Med Chem 65:9548-9563 (2022) [PubMed] 
Target
Name:
Nuclear receptor subfamily 4 group A member 2
Synonyms:
NR4A2_MOUSE | NUR-related factor 1 | Nr4a2 | Nuclear receptor subfamily 4 group A member 2 | Nurr1 | Orphan nuclear receptor NURR1
Type:
PROTEIN
Mol. Mass.:
66605.74
Organism:
Mus musculus
Description:
ChEMBL_116964
Residue:
598
Sequence:
MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSMDLTNTEITATTSLPSFSTFMDNYSTGYDVKPPCLYQMPLSGQQSSIKVEDIQMHNYQQHSHLPPQSEEMMPHSGSVYYKPSSPPTPSTPSFQVQHSPMWDDPGSLHNFHQNYVATTHMIEQRKTPVSRLSLFSFKQSPPGTPVSSCQMRFDGPLHVPMNPEPAGSHHVVDGQTFAVPNPIRKPASMGFPGLQIGHASQLLDTQVPSPPSRGSPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQDPSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF
  
Inhibitor
Name:
BDBM50318491
Synonyms:
7-((1R,2S)-2-((S)-3-hydroxyoct-1-enyl)-5-oxocyclopent-3-enyl)heptanoic acid | CHEMBL1084644
Type:
Small organic molecule
Emp. Form.:
C20H32O4
Mol. Mass.:
336.4657
SMILES:
CCCCC[C@H](O)C=C[C@H]1C=CC(=O)[C@@H]1CCCCCCC(O)=O |r,c:10|
Structure:
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