Reaction Details Report a problem with these data
Target
Nuclear receptor subfamily 4 group A member 2
Ligand
BDBM50250885
Substrate
n/a
Meas. Tech.
ChEMBL_2227573 (CHEMBL5141086)
IC50
48000±n/a nM
Citation
 Willems, S; Merk, D Medicinal Chemistry and Chemical Biology of Nurr1 Modulators: An Emerging Strategy in Neurodegeneration. J Med Chem 65:9548-9563 (2022) [PubMed] 
Target
Name:
Nuclear receptor subfamily 4 group A member 2
Synonyms:
NOT | NR4A2 | NR4A2_HUMAN | NURR1 | TINUR
Type:
PROTEIN
Mol. Mass.:
66603.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_453027
Residue:
598
Sequence:
MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSMDLTNTEITATTSLPSFSTFMDNYSTGYDVKPPCLYQMPLSGQQSSIKVEDIQMHNYQQHSHLPPQSEEMMPHSGSVYYKPSSPPTPTTPGFQVQHSPMWDDPGSLHNFHQNYVATTHMIEQRKTPVSRLSLFSFKQSPPGTPVSSCQMRFDGPLHVPMNPEPAGSHHVVDGQTFAVPNPIRKPASMGFPGLQIGHASQLLDTQVPSPPSRGSPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQEPSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF
  
Inhibitor
Name:
BDBM50250885
Synonyms:
CHEBI:65019 | CHEMBL2270066
Type:
Small organic molecule
Emp. Form.:
C10H9NO2
Mol. Mass.:
175.184
SMILES:
COC(=O)c1c[nH]c2ccccc12
Structure:
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