Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50598697
Substrate
n/a
Meas. Tech.
ChEMBL_2227759 (CHEMBL5141272)
Ki
0.250000±n/a nM
Citation
 Rosse, G Spiro-naphthyridine Antagonists of the Melanocortin Receptor 4 for the Treatment of Cachexia Associated with Chronic Illness. ACS Med Chem Lett 13:997-998 (2022) [PubMed] 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50598697
Synonyms:
CHEMBL5179337
Type:
Small organic molecule
Emp. Form.:
C25H27ClN6O2
Mol. Mass.:
478.974
SMILES:
COc1cc([C@@H](C)C(=O)N2CC[C@]3(C2)CCc2cc(c(C)nc2N3)-c2ncccn2)c(Cl)cn1 |r|
Structure:
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