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Target
Cytochrome c oxidase subunit 2
Ligand
BDBM50598750
Substrate
n/a
Meas. Tech.
ChEMBL_2227920 (CHEMBL5141433)
IC50
490±n/a nM
Citation
 Li, J; Hu, X; Zhang, H; Peng, Y; Li, S; Xiong, Y; Jiang, W; Wang, Z -2-(Phenylamino) Benzamide Derivatives as Dual Inhibitors of COX-2 and Topo I Deter Gastrointestinal Cancers via Targeting Inflammation and Tumor Progression. J Med Chem 65:10481-10505 (2022) [PubMed] 
Target
Name:
Cytochrome c oxidase subunit 2
Synonyms:
COII | COX2 | COX2_HUMAN | COXII | MT-CO2 | MTCO2
Type:
PROTEIN
Mol. Mass.:
25555.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_530099
Residue:
227
Sequence:
MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFLTLTTKLTNTNISDAQEMETVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGHQWYWTYEYTDYGGLIFNSYMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQDVLHSWAVPTLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKIFEMGPVFTL
  
Inhibitor
Name:
BDBM50598750
Synonyms:
CHEMBL5193981
Type:
Small organic molecule
Emp. Form.:
C21H19ClN2O2
Mol. Mass.:
366.841
SMILES:
Cc1c(Cl)cccc1Nc1ccccc1C(=O)NCc1ccc(O)cc1
Structure:
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