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Target
Coagulation factor VII
Ligand
BDBM16303
Substrate
n/a
Meas. Tech.
ChEMBL_334356 (CHEMBL862508)
Ki
26000±n/a nM
Citation
 Young, WB; Sprengeler, P; Shrader, WD; Li, Y; Rai, R; Verner, E; Jenkins, T; Fatheree, P; Kolesnikov, A; Janc, JW; Cregar, L; Elrod, K; Katz, B Generation of potent coagulation protease inhibitors utilizing zinc-mediated chelation. Bioorg Med Chem Lett 16:710-3 (2005) [PubMed]  Article 
Target
Name:
Coagulation factor VII
Synonyms:
Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator
Type:
Enzyme
Mol. Mass.:
51599.89
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
466
Sequence:
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
  
Inhibitor
Name:
BDBM16303
Synonyms:
2-(1H-1,3-benzodiazol-2-ylmethyl)-1H-1,3-benzodiazole-6-carboximidamide | 2-(1H-benzimidazol-2-ylmethyl)-1H-benzimidazole-6-carboximidamide | APD-1 | CHEMBL46148
Type:
Small organic molecule
Emp. Form.:
C16H14N6
Mol. Mass.:
290.3226
SMILES:
NC(=N)c1ccc2nc(Cc3nc4ccccc4[nH]3)[nH]c2c1
Structure:
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