Reaction Details Report a problem with these data
Target
Prothrombin
Ligand
BDBM16303
Substrate
n/a
Meas. Tech.
ChEMBL_334355 (CHEMBL862507)
Ki
70000±n/a nM
Citation
Young, WB; Sprengeler, P; Shrader, WD; Li, Y; Rai, R; Verner, E; Jenkins, T; Fatheree, P; Kolesnikov, A; Janc, JW; Cregar, L; Elrod, K; Katz, B Generation of potent coagulation protease inhibitors utilizing zinc-mediated chelation. Bioorg Med Chem Lett 16:710-3 (2005) [PubMed] Article
More Info.:
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain
Type:
Protein
Mol. Mass.:
70029.57
Organism:
Homo sapiens (Human)
Description:
P00734
Residue:
622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
Inhibitor
Name:
BDBM16303
Synonyms:
2-(1H-1,3-benzodiazol-2-ylmethyl)-1H-1,3-benzodiazole-6-carboximidamide | 2-(1H-benzimidazol-2-ylmethyl)-1H-benzimidazole-6-carboximidamide | APD-1 | CHEMBL46148
Type:
Small organic molecule
Emp. Form.:
C16H14N6
Mol. Mass.:
290.3226
SMILES:
NC(=N)c1ccc2nc(Cc3nc4ccccc4[nH]3)[nH]c2c1