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Target
Cholinesterase
Ligand
BDBM8958
Substrate
n/a
Meas. Tech.
ChEMBL_2229104 (CHEMBL5142617)
Ki
20±n/a nM
Citation
 Du, C; Wang, L; Guan, Q; Yang, H; Chen, T; Liu, Y; Li, Q; Lyu, W; Lu, X; Chen, Y; Liu, Y; Liu, H; Feng, F; Liu, W; Liu, Z; Li, W; Chen, Y; Sun, H -Benzyl Benzamide Derivatives as Selective Sub-Nanomolar Butyrylcholinesterase Inhibitors for Possible Treatment in Advanced Alzheimer's Disease. J Med Chem 65:11365-11387 (2022) [PubMed] 
Target
Name:
Cholinesterase
Synonyms:
Acylcholine acylhydrolase | BCHE | Butyrylcholine esterase (BChE) | Butyrylcholinesterase (BChE) | Butyrylcholinesterase (BuChE) | CHE1 | CHLE_HUMAN | Choline esterase II | Cholinesterases | Cholinesterases; ACHE & BCHE | Pseudocholinesterase
Type:
Homotetramer
Mol. Mass.:
68422.27
Organism:
Homo sapiens (Human)
Description:
P06276
Residue:
602
Sequence:
MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCVGL
  
Inhibitor
Name:
BDBM8958
Synonyms:
10-(2-diethylaminopropyl)phenothiazine | CHEMBL1200970 | CHEMBL1206 | Ethopropazine | diethyl[1-(10H-phenothiazin-10-yl)propan-2-yl]amine
Type:
Small organic molecule
Emp. Form.:
C19H24N2S
Mol. Mass.:
312.472
SMILES:
CCN(CC)C(C)CN1c2ccccc2Sc2ccccc12
Structure:
Search PDB for entries with ligand similarity: