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Target
Proteasome subunit beta type-1
Ligand
BDBM50599552
Substrate
n/a
Meas. Tech.
ChEMBL_2230872 (CHEMBL5144644)
Ki
3000±n/a nM
Citation
 Ettari, R; Iraci, N; Di Chio, C; Previti, S; Danzč, M; Zappalą, M Development of isoquinolinone derivatives as immunoproteasome inhibitors. Bioorg Med Chem Lett 55:0 (2022) [PubMed] 
Target
Name:
Proteasome subunit beta type-1
Synonyms:
PSB1_HUMAN | PSC5 | PSMB1 | Proteasome component C5 | Proteasome subunit beta type-1/beta type-5
Type:
PROTEIN
Mol. Mass.:
26493.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1366691
Residue:
241
Sequence:
MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRKD
  
Inhibitor
Name:
BDBM50599552
Synonyms:
CHEMBL5195299
Type:
Small organic molecule
Emp. Form.:
C22H22N2O4
Mol. Mass.:
378.4211
SMILES:
COc1cc2ccn(C\C=C\C(=O)NCc3ccccc3)c(=O)c2cc1OC
Structure:
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