Reaction Details Report a problem with these data
Target
Short transient receptor potential channel 4
Ligand
BDBM50599832
Substrate
n/a
Meas. Tech.
ChEMBL_2231868 (CHEMBL5145640)
IC50
65±n/a nM
Citation
 Zhang, Z; Chen, L; Tian, H; Liu, M; Jiang, S; Shen, J; Wang, K; Cao, Z Discovery of pyrroledione analogs as potent transient receptor potential canonical channel 5 inhibitors. Bioorg Med Chem Lett 61:0 (2022) [PubMed] 
Target
Name:
Short transient receptor potential channel 4
Synonyms:
Short transient receptor potential channel 4 | TRPC4 | TRPC4_HUMAN | Trp-related protein 4 | hTrp-4 | hTrp4
Type:
PROTEIN
Mol. Mass.:
112112.80
Organism:
Homo sapiens
Description:
ChEMBL_118216
Residue:
977
Sequence:
MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGRRAADNLRRHHQYQEVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESSNSADSDEKSDSEGNSKDKKKNFSLFDLTTLIHPRSAAIASERHNISNGSALVVQEPPREKQRKVNFVTDIKNFGLFHRRSKQNAAEQNANQIFSVSEEVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDHRERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHEDYVTTRL
  
Inhibitor
Name:
BDBM50599832
Synonyms:
CHEMBL5201831
Type:
Small organic molecule
Emp. Form.:
C18H11ClF4N4O3
Mol. Mass.:
442.752
SMILES:
Fc1ccc(Oc2ncnc3CN(CCc23)C2=C(Cl)C(=O)NC2=O)c(c1)C(F)(F)F |c:18|
Structure:
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