Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 14
Ligand
BDBM50528810
Substrate
n/a
Meas. Tech.
ChEMBL_2232550 (CHEMBL5146322)
IC50
39±n/a nM
Citation
 Xie, Z; Hou, S; Yang, X; Duan, Y; Han, J; Wang, Q; Liao, C Lessons Learned from Past Cyclin-Dependent Kinase Drug Discovery Efforts. J Med Chem 65:6356-6389 (2022) [PubMed] 
Target
Name:
Cyclin-dependent kinase 14
Synonyms:
CDK14 | CDK14_HUMAN | KIAA0834 | PFTK1 | Serine/threonine-protein kinase PFTAIRE-1
Type:
PROTEIN
Mol. Mass.:
53075.39
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774550
Residue:
469
Sequence:
MCDLIEPQPAEKIGKMKKLRRTLSESFSRIALKKDDTTFDEICVTKMSTRNCQGMDSVIKPLDTIPEDKKVRVQRTQSTFDPFEKPANQVKRVHSENNACINFKTSSTGKESPKVRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAFGKNNSYGKSLSNSKH
  
Inhibitor
Name:
BDBM50528810
Synonyms:
CHEMBL4580787
Type:
Small organic molecule
Emp. Form.:
C28H30Cl3N7O5S
Mol. Mass.:
683.006
SMILES:
CN(C)C\C=C\C(=O)Nc1cccc(c1)S(=O)(=O)N1CCC(CC1)NC(=O)c1n[nH]cc1NC(=O)c1c(Cl)cc(Cl)cc1Cl
Structure:
Search PDB for entries with ligand similarity: