Reaction Details Report a problem with these data
Target
Monoglyceride lipase
Ligand
BDBM50600140
Substrate
n/a
Meas. Tech.
ChEMBL_2233100 (CHEMBL5146872)
Ki
60±n/a nM
Citation
 Jaiswal, S; Akhilesh, na; Uniyal, A; Tiwari, V; Raja Ayyannan, S Synthesis and evaluation of dual fatty acid amide hydrolase-monoacylglycerol lipase inhibition and antinociceptive activities of 4-methylsulfonylaniline-derived semicarbazones. Bioorg Med Chem 60:0 (2022) [PubMed] 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM50600140
Synonyms:
CHEMBL5174588
Type:
Small organic molecule
Emp. Form.:
C15H13Cl2N3O3S
Mol. Mass.:
386.253
SMILES:
CS(=O)(=O)c1ccc(NC(=O)N\N=C/c2c(Cl)cccc2Cl)cc1
Structure:
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