Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50178622
Substrate
n/a
Meas. Tech.
ChEMBL_325303 (CHEMBL859710)
Ki
20.6±n/a nM
Citation
 Leopoldo, M; Lacivita, E; Colabufo, NA; Contino, M; Berardi, F; Perrone, R First structure-activity relationship study on dopamine D3 receptor agents with N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamide structure. J Med Chem 48:7919-22 (2005) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50178622
Synonyms:
CHEMBL277301 | cis-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-4-phenylcyclohexanecarboxamide
Type:
Small organic molecule
Emp. Form.:
C28H39N3O2
Mol. Mass.:
449.6282
SMILES:
COc1ccccc1N1CCN(CCCCNC(=O)[C@H]2CC[C@H](CC2)c2ccccc2)CC1 |wD:19.19,22.26,(31.7,-13.48,;30.37,-12.69,;30.4,-11.16,;31.74,-10.4,;31.76,-8.86,;30.43,-8.08,;29.09,-8.83,;29.08,-10.36,;27.74,-11.12,;27.72,-12.66,;26.38,-13.41,;25.07,-12.62,;23.73,-13.38,;23.71,-14.92,;22.37,-15.7,;21.04,-14.93,;21.04,-13.39,;19.7,-12.62,;19.7,-11.08,;18.37,-13.39,;17.04,-12.61,;15.71,-13.37,;15.7,-14.92,;17.03,-15.69,;18.37,-14.92,;14.36,-15.68,;13.03,-14.9,;11.7,-15.67,;11.69,-17.21,;13.03,-17.98,;14.36,-17.21,;25.06,-11.09,;26.41,-10.33,)|
Structure:
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