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Target
Sodium-dependent phosphate transport protein 2B
Ligand
BDBM50600220
Substrate
n/a
Meas. Tech.
ChEMBL_2233369 (CHEMBL5147141)
IC50
10.0±n/a nM
Citation
 Ushiki, Y; Kawabe, K; Yamamoto-Okada, K; Uneuchi, F; Asanuma, Y; Yamaguchi, C; Ohta, H; Shibata, T; Abe, T; Okumura-Kitajima, L; Kosai, Y; Endo, M; Otake, K; Munetomo, E; Takahashi, T; Kakinuma, H Design, synthesis and biological evaluation of novel pyridine derivatives as gut-selective NaPi2b inhibitors. Bioorg Med Chem Lett 65:0 (2022) [PubMed] 
Target
Name:
Sodium-dependent phosphate transport protein 2B
Synonyms:
NPT2B_RAT | Na(+)-dependent phosphate cotransporter 2B | Na(+)/Pi cotransporter 2B | NaPi-2b | Slc34a2 | Sodium-phosphate transport protein 2B | Sodium/phosphate cotransporter 2B | Solute carrier family 34 member 2 | rNaPi IIb
Type:
PROTEIN
Mol. Mass.:
75997.72
Organism:
Rattus norvegicus
Description:
ChEMBL_120738
Residue:
695
Sequence:
MAPWPELENAHPNPNKFIEGASGPQSSIPDKDKGTSKTNDSGTPVAKIELLPSYSALVLIEEPPEGNDPWDLPELQDNGIKWSERDSKGKILCIFQGIGKFILLLGFLYLFVCSLDVLSSAFQLVGGKMAGQFFSNNSIMSNPVAGLVIGVLVTVMVQSSSTSSSIIVSMVASSLLSVRAAIPIIMGANIGTSITNTIVALMQAGDRNEFRRAFAGATVHDFFNWLSVLVLLPLEAATHYLEKLTNLVLETFSFQNGEDAPDILKVITDPFTKLIIQLDKKVIQQIAMGDSEAQNKSLIKIWCKTISNVIEENVTVPSPDNCTSPSYCWTDGIQTWTIQNVTEKENIAKCQHIFVNFSLPDLAVGIILLTVSLLILCGCLIMIVKLLGSVLRGQVATVIKKTLNTDFPFPFAWLTGYLAILVGAGMTFIVQSSSVFTSAMTPLIGIGVISIERAYPLTLGSNIGTTTTAILAALASPGNTLRSSLQIALCHFFFNISGILLWYPIPFTRLPIRLAKGLGNISAKYRWFAVFYLIFFFLLTPLTVFGLSLAGWPVLVGVGVPIILLILLVLCLRMLQARCPRILPLKLRDWNFLPLWMHSLKPWDNIISLATSCFQRRCCCCCRVCCRVCCMVCGCKCCRCSKCCKNLEEEEKEQDVPVKASGGFDNTAMSKECQDEGKGQVEVLGMKALSNTTVF
  
Inhibitor
Name:
BDBM50600220
Synonyms:
CHEMBL5177872
Type:
Small organic molecule
Emp. Form.:
C43H51N7O9S2
Mol. Mass.:
874.037
SMILES:
CCN([C@H]1CC[C@@H](CC1)C(O)=O)S(=O)(=O)c1cccc(c1)C(=O)Nc1ccc(nc1C(=O)Nc1ccc(CCc2ccc(cc2)C(=O)NS(=O)(=O)NC)cc1)N1CCCCC1 |r,wU:6.9,wD:3.2,(2.67,-6.93,;1.33,-6.16,;1.33,-4.62,;2.67,-3.85,;4,-4.62,;5.33,-3.85,;5.33,-2.31,;4,-1.54,;2.67,-2.31,;6.67,-1.54,;8,-2.31,;6.67,-0,;-0,-3.85,;.77,-2.52,;-.77,-2.52,;-1.33,-4.62,;-1.33,-6.16,;-2.66,-6.93,;-4,-6.17,;-4,-4.62,;-2.66,-3.85,;-5.33,-3.85,;-6.66,-4.62,;-5.33,-2.31,;-6.66,-1.54,;-8,-2.31,;-9.33,-1.54,;-9.33,-.01,;-8,.77,;-6.66,-0,;-5.33,.77,;-5.33,2.31,;-4,-0,;-2.66,.77,;-2.66,2.31,;-1.33,3.08,;-0,2.31,;1.33,3.08,;2.67,2.31,;4,3.08,;4,4.63,;5.33,5.39,;6.66,4.62,;6.67,3.09,;5.34,2.31,;8,5.39,;8,6.93,;9.33,4.62,;10.67,5.39,;11.44,6.73,;9.9,6.73,;12,4.62,;13.33,5.39,;-0,.77,;-1.33,.01,;-10.67,.76,;-12,-.01,;-13.33,.76,;-13.33,2.3,;-12,3.07,;-10.67,2.3,)|
Structure:
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