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Target
Bile salt-activated lipase
Ligand
BDBM50179317
Substrate
n/a
Meas. Tech.
ChEMBL_325182 (CHEMBL861460)
Ki
>50000±n/a nM
Citation
 Pietsch, M; Gütschow, M Synthesis of tricyclic 1,3-oxazin-4-ones and kinetic analysis of cholesterol esterase and acetylcholinesterase inhibition. J Med Chem 48:8270-88 (2005) [PubMed]  Article 
Target
Name:
Bile salt-activated lipase
Synonyms:
CEL | CEL_BOVIN | Cholesterol esterase
Type:
PROTEIN
Mol. Mass.:
65152.77
Organism:
Bos taurus
Description:
ChEMBL_154778
Residue:
597
Sequence:
LGASRLGPSPGCLAVASAAKLGSVYTEGGFVEGVNKKLSLFGDSIDIFKGIPFAAAPKALEKPERHPGWQGTLKAKSFKKRCLQATLTQDSTYGNEDCLYLNIWVPQGRKEVSHDLPVMIWIYGGAFLMGASQGANFLSNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDSNLPGNYGLWDQHMAIAWVKRNIEAFGGDPDNITLFGESAGGASVSLQTLSPYNKGLIKRAISQSGVGLCPWAIQQDPLFWAKRIAEKVGCPVDDTSKMAGCLKITDPRALTLAYKLPLGSTEYPKLHYLSFVPVIDGDFIPDDPVNLYANAADVDYIAGTNDMDGHLFVGMDVPAINSNKQDVTEEDFYKLVSGLTVTKGLRGANATYEVYTEPWAQDSSQETRKKTMVDLETDILFLIPTKIAVAQHKSHAKSANTYTYLFSQPSRMPIYPKWMGADHADDLQYVFGKPFATPLGYRAQDRTVSKAMIAYWTNFARTGDPNTGHSTVPANWDPYTLEDDNYLEINKQMDSNSMKLHLRTNYLQFWTQTYQALPTVTSAGASLLPPEDNSQASPVPPADNSGAPTEPSAGDSEVAQMPVVIGF
  
Inhibitor
Name:
BDBM50179317
Synonyms:
7-benzyl-2-(4-benzyl-piperazin-1-yl)-5,6,7,8-tetrahydro-4H-pyrido[4',3':4,5]thieno[2,3-d][1,3]oxazin-4-one | CHEMBL107585
Type:
Small organic molecule
Emp. Form.:
C27H28N4O2S
Mol. Mass.:
472.602
SMILES:
O=c1oc(nc2sc3CN(Cc4ccccc4)CCc3c12)N1CCN(Cc2ccccc2)CC1
Structure:
Search PDB for entries with ligand similarity: