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Target
Fatty-acid amide hydrolase 1
Ligand
BDBM50600503
Substrate
n/a
Meas. Tech.
ChEMBL_2234320 (CHEMBL5148092)
IC50
11±n/a nM
Citation
 Fulp, A; Bingham, S; Fisler, B; Kho, F; Kim, J; Kim, SJ; Martin, T; Mims, B; Reji Thomas, K; Roe, G; Spiotta, J; Young, J; Lazenka, M Design and synthesis of endocannabinoid enzyme inhibitors for ocular indications. Bioorg Med Chem Lett 68:0 (2022) [PubMed] 
Target
Name:
Fatty-acid amide hydrolase 1
Synonyms:
Anandamide amidohydrolase | Anandamide amidohydrolase 1 | FAAH1_MOUSE | Faah | Faah1 | Fatty Acid Amide Hydrolase | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1
Type:
Hydrolase; single-pass membrane protein; homodimer
Mol. Mass.:
63227.28
Organism:
Mus musculus (mouse)
Description:
Mouse brain membranes were used in the assay.
Residue:
579
Sequence:
MVLSEVWTALSGLSGVCLACSLLSAAVVLRWTRSQTARGAVTRARQKQRAGLETMDKAVQRFRLQNPDLDSEALLALPLLQLVQKLQSGELSPEAVLFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHASTLGLSLNEGVTSESDCVVVQVLKLQGAVPFVHTNVPQSMLSYDCSNPLFGQTMNPWKPSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKSCVYGQTAVQLSVGPMARDVDSLALCMKALLCEDLFRLDSTIPPLPFREEIYRSSRPLRVGYYETDNYTMPTPAMRRAVMETKQSLEAAGHTLVPFLPNNIPYALEVLSAGGLFSDGGCSFLQNFKGDFVDPCLGDLVLVLKLPRWFKKLLSFLLKPLFPRLAAFLNSMCPRSAEKLWELQHEIEMYRQSVIAQWKAMNLDVVLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMEHYKGYFGDMWDNILKKGMKKGIGLPVAVQCVALPWQEELCLRFMREVERLMTPEKRPS
  
Inhibitor
Name:
BDBM50600503
Synonyms:
CHEMBL5203286
Type:
Small organic molecule
Emp. Form.:
C21H19N3O6S
Mol. Mass.:
441.457
SMILES:
[O-][N+](=O)c1ccc(OC(=O)N2CCN(CC2)S(=O)(=O)c2ccc3ccccc3c2)cc1
Structure:
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