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Target
5'-AMP-activated protein kinase subunit beta-2
Ligand
BDBM50600528
Substrate
n/a
Meas. Tech.
ChEMBL_2234479 (CHEMBL5148251)
EC50
1300±n/a nM
Citation
 Tamura, Y; Morita, I; Hinata, Y; Kojima, E; Ozasa, H; Ikemoto, H; Asano, M; Wada, T; Hayasaki-Kajiwara, Y; Iwasaki, T; Matsumura, K Identification of novel indole derivatives as highly potent AMPK activators with anti-diabetic profiles. Bioorg Med Chem Lett 68:0 (2022) [PubMed] 
Target
Name:
5'-AMP-activated protein kinase subunit beta-2
Synonyms:
AAKB2_HUMAN | AMPK alpha2/beta2/gamma3 | AMPK subunit beta-2 | PRKAB2
Type:
PROTEIN
Mol. Mass.:
30301.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107883
Residue:
272
Sequence:
MGNTTSDRVSGERHGAKAARSEGAGGHAPGKEHKIMVGSTDDPSVFSLPDSKLPGDKEFVSWQQDLEDSVKPTQQARPTVIRWSEGGKEVFISGSFNNWSTKIPLIKSHNDFVAILDLPEGEHQYKFFVDGQWVHDPSEPVVTSQLGTINNLIHVKKSDFEVFDALKLDSMESSETSCRDLSSSPPGPYGQEMYAFRSEERFKSPPILPPHLLQVILNKDTNISCDPALLPEPNHVMLNHLYALSIKDSVMVLSATHRYKKKYVTTLLYKPI
  
Inhibitor
Name:
BDBM50600528
Synonyms:
CHEMBL5191686
Type:
Small organic molecule
Emp. Form.:
C23H20ClNO3S
Mol. Mass.:
425.928
SMILES:
OC1=C(C(=O)NC2SC(Cl)=C(C12)c1ccc2CCCCc2c1O)c1ccccc1 |c:9,t:1|
Structure:
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