Reaction Details Report a problem with these data
Target
Peroxisome proliferator-activated receptor delta
Ligand
BDBM50179823
Substrate
n/a
Meas. Tech.
ChEMBL_339275 (CHEMBL867228)
IC50
134±n/a nM
Citation
 Desai, RC; Metzger, E; Santini, C; Meinke, PT; Heck, JV; Berger, JP; MacNaul, KL; Cai, TQ; Wright, SD; Agrawal, A; Moller, DE; Sahoo, SP Design and synthesis of potent and subtype-selective PPARalpha agonists. Bioorg Med Chem Lett 16:1673-8 (2006) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor delta
Synonyms:
NR1C2 | NUC1 | NUCI | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | PPAR delta | PPAR-beta | PPARB | PPARD | PPARD_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor beta | Peroxisome proliferator-activated receptor delta
Type:
Enzyme
Mol. Mass.:
49910.45
Organism:
Homo sapiens (Human)
Description:
Q03181
Residue:
441
Sequence:
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY
  
Inhibitor
Name:
BDBM50179823
Synonyms:
(S)-2-methyl-2-((4-(3-(8-methyl-2-oxo-4-(trifluoromethyl)-2H-chromen-7-yloxy)propoxy)phenyl)methyl)butanoic acid | CHEMBL205777
Type:
Small organic molecule
Emp. Form.:
C26H27F3O6
Mol. Mass.:
492.4842
SMILES:
CC[C@@](C)(Cc1ccc(OCCCOc2ccc3c(cc(=O)oc3c2C)C(F)(F)F)cc1)C(O)=O
Structure:
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