Reaction Details Report a problem with these data
Target
Peroxisome proliferator-activated receptor delta
Ligand
BDBM50179839
Substrate
n/a
Meas. Tech.
ChEMBL_339275 (CHEMBL867228)
IC50
1340±n/a nM
Citation
 Desai, RC; Metzger, E; Santini, C; Meinke, PT; Heck, JV; Berger, JP; MacNaul, KL; Cai, TQ; Wright, SD; Agrawal, A; Moller, DE; Sahoo, SP Design and synthesis of potent and subtype-selective PPARalpha agonists. Bioorg Med Chem Lett 16:1673-8 (2006) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor delta
Synonyms:
NR1C2 | NUC1 | NUCI | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | PPAR delta | PPAR-beta | PPARB | PPARD | PPARD_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor beta | Peroxisome proliferator-activated receptor delta
Type:
Enzyme
Mol. Mass.:
49910.45
Organism:
Homo sapiens (Human)
Description:
Q03181
Residue:
441
Sequence:
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY
  
Inhibitor
Name:
BDBM50179839
Synonyms:
3-(4-(3-(2-chloro-4-(4-fluorophenoxy)phenoxy)propoxy)phenyl)-2-phenylpropanoic acid | CHEMBL202785
Type:
Small organic molecule
Emp. Form.:
C30H26ClFO5
Mol. Mass.:
520.976
SMILES:
OC(=O)C(Cc1ccc(OCCCOc2ccc(Oc3ccc(F)cc3)cc2Cl)cc1)c1ccccc1
Structure:
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