Reaction Details Report a problem with these data
Target
Major prion protein
Ligand
BDBM50600940
Substrate
n/a
Meas. Tech.
ChEMBL_2235420 (CHEMBL5149192)
IC50
950±n/a nM
Citation
 Colini Baldeschi, A; Zattoni, M; Vanni, S; Nikolic, L; Ferracin, C; La Sala, G; Summa, M; Bertorelli, R; Bertozzi, SM; Giachin, G; Carloni, P; Bolognesi, ML; De Vivo, M; Legname, G Innovative Non-PrP-Targeted Drug Strategy Designed to Enhance Prion Clearance. J Med Chem 65:8998-9010 (2022) [PubMed] 
Target
Name:
Major prion protein
Synonyms:
PRIO_MOUSE | Prion protein | Prn-p | Prnp | Prp
Type:
PROTEIN
Mol. Mass.:
27989.70
Organism:
Mus musculus
Description:
ChEMBL_691098
Residue:
254
Sequence:
MANLGYWLLALFVTMWTDVGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGTWGQPHGGGWGQPHGGSWGQPHGGSWGQPHGGGWGQGGGTHNQWNKPSKPKTNLKHVAGAAAAGAVVGGLGGYMLGSAMSRPMIHFGNDWEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAYYDGRRSSSTVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM50600940
Synonyms:
CHEMBL5081846
Type:
Small organic molecule
Emp. Form.:
C16H17F3N4O2
Mol. Mass.:
354.327
SMILES:
Nc1c(cnn1-c1ccc(OC(F)(F)F)cc1)C(=O)C1CCNCC1
Structure:
Search PDB for entries with ligand similarity: