Reaction Details Report a problem with these data
Target
Matrix metalloproteinase-16
Ligand
BDBM50180601
Substrate
n/a
Meas. Tech.
ChEMBL_330173 (CHEMBL863526)
IC50
32040±n/a nM
Citation
 Ma, D; Jiang, Y; Chen, F; Gong, LK; Ding, K; Xu, Y; Wang, R; Ge, A; Ren, J; Li, J; Li, J; Ye, Q Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids. J Med Chem 49:456-8 (2006) [PubMed]  Article 
Target
Name:
Matrix metalloproteinase-16
Synonyms:
C8orf57 | MMP-16 | MMP-X2 | MMP16 | MMP16_HUMAN | MMPX2 | MT-MMP 3 | MT3-MMP | MT3MMP | MTMMP3 | Matrix metalloproteinase 16 | Matrix metalloproteinase-16 | Membrane-type matrix metalloproteinase 3 | Membrane-type-3 matrix metalloproteinase
Type:
PROTEIN
Mol. Mass.:
69536.76
Organism:
Homo sapiens (Human)
Description:
ChEMBL_799129
Residue:
607
Sequence:
MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV
  
Inhibitor
Name:
BDBM50180601
Synonyms:
3-(4-(2-phenylethynyl)benzoyl)pentanoic acid | CHEMBL202875
Type:
Small organic molecule
Emp. Form.:
C20H18O3
Mol. Mass.:
306.3551
SMILES:
CCC(CC(O)=O)C(=O)c1ccc(cc1)C#Cc1ccccc1
Structure:
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