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Target
Short transient receptor potential channel 5
Ligand
BDBM50601266
Substrate
n/a
Meas. Tech.
ChEMBL_2236096 (CHEMBL5149868)
EC50
1250±n/a nM
Citation
 Seenadera, SPD; Long, SA; Akee, R; Bermudez, G; Parsonage, G; Strope, J; Peer, C; Figg, WD; Parker, KA; Beech, DJ; Beutler, JA Biological Effects of Modifications of the Englerin A Glycolate. ACS Med Chem Lett 13:1472-1476 (2022) [PubMed] 
Target
Name:
Short transient receptor potential channel 5
Synonyms:
TRP5 | TRPC5 | TRPC5_HUMAN | Transient receptor protein 5 (TRPC5)
Type:
Enzyme
Mol. Mass.:
111421.47
Organism:
Homo sapiens (Human)
Description:
Q9UL62
Residue:
973
Sequence:
MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRRPSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRRNLRSFTERNADSLIQNQHYQEVIRNLVKRYVAAMIRNSKTHEGLTEENFKELKQDISSFRYEVLDLLGNRKHPRSFSTSSTELSQRDDNNDGSGGARAKSKSVSFNLGCKKKTCHGPPLIRTMPRSSGAQGKSKAESSSKRSFMGPSLKKLGLLFSKFNGHMSEPSSEPMYTISDGIVQQHCMWQDIRYSQMEKGKAEACSQSEINLSEVELGEVQGAAQSSECPLACSSSLHCASSICSSNSKLLDSSEDVFETWGEACDLLMHKWGDGQEEQVTTRL
  
Inhibitor
Name:
BDBM50601266
Synonyms:
CHEMBL5173479
Type:
Small organic molecule
Emp. Form.:
C31H40O7
Mol. Mass.:
524.6451
SMILES:
[H][C@@]12[#6]-[#6]-[#6@@H](-[#6])[C@@]1([H])[#6@H](-[#8]-[#6](=O)\[#6]=[#6]\c1ccccc1)[C@@]1([#6]-[#6@@H](-[#8]-[#6](=O)-[#6]-[#8]-[#6](=O)\[#6]=[#6](\[#6])-[#6])[C@@]2([#6])[#8]1)[#6](-[#6])-[#6] |r|
Structure:
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