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Target
GTPase NRas
Ligand
BDBM50097071
Substrate
n/a
Meas. Tech.
ChEMBL_2236259 (CHEMBL5150155)
Ki
0.300000±n/a nM
Citation
 Korzeniecki, C; Priefer, R Targeting KRAS mutant cancers by preventing signaling transduction in the MAPK pathway. Eur J Med Chem 211:0 (2021) [PubMed] 
Target
Name:
GTPase NRas
Synonyms:
HRAS1 | NRAS | RASN_HUMAN | Transforming protein N-Ras
Type:
PROTEIN
Mol. Mass.:
21223.91
Organism:
Homo sapiens (Human)
Description:
ChEMBL_839699
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM
  
Inhibitor
Name:
BDBM50097071
Synonyms:
4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE | 4-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmethyl]-imidazol-1-ylmethyl}-benzonitrile | CHEMBL279433 | L-778123
Type:
Small organic molecule
Emp. Form.:
C22H20ClN5O
Mol. Mass.:
405.88
SMILES:
Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(cc2)C#N)CC1=O
Structure:
Search PDB for entries with ligand similarity: