Reaction Details Report a problem with these data
Target
GTPase HRas
Ligand
BDBM50097071
Substrate
n/a
Meas. Tech.
ChEMBL_2236260 (CHEMBL5150156)
Ki
1.6±n/a nM
Citation
 Korzeniecki, C; Priefer, R Targeting KRAS mutant cancers by preventing signaling transduction in the MAPK pathway. Eur J Med Chem 211:0 (2021) [PubMed] 
Target
Name:
GTPase HRas
Synonyms:
GTPase HRas, N-terminally processed | H-Ras | H-Ras-1 | HRAS | HRAS1 | Ha-Ras | His6-Ha-Ras-CVLS | RASH_HUMAN | Transforming protein p21 | Transforming protein p21/H-Ras-1 | Wild-type Ha-Ras | c-H-ras | p21ras
Type:
Other Protein Type
Mol. Mass.:
21293.37
Organism:
Homo sapiens (Human)
Description:
P01112
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS
  
Inhibitor
Name:
BDBM50097071
Synonyms:
4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE | 4-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmethyl]-imidazol-1-ylmethyl}-benzonitrile | CHEMBL279433 | L-778123
Type:
Small organic molecule
Emp. Form.:
C22H20ClN5O
Mol. Mass.:
405.88
SMILES:
Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(cc2)C#N)CC1=O
Structure:
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